PDF | The majority of oral diseases present as growths and masses of varied cellular origin. Such masses may include simple hyperplasia. The presence of a neurovascular hamartoma within the oral cavity is truly a rare entity. Scarcely reported in the literature, these hamartomas. Cowden’s Syndrome, Bannayan-Riley-Ruvalcaba Syndrome, PTEN Hamartoma Tumour Syndrome.
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Irregularly formed cemental matrix with entrapped cells. The fibrous connective tissue stroma is loose, may contain multinucleated giant cells cementoclasts and numerous dilated small blood vessels which is the hallmark of the lesion [11,12] Figure 1.
There is a formation of the dentinoid or osteodentin material with an occasional presence of enamel fibrillar and key orak patterns. This article has been cited by other articles in PMC. Comparison with hyperplastic dental follicles. Shankargouda PatilRoopa S.
Ameloblastic fibro-odontoma ABFO is considered to be a hamartomatous tumour which holds similarity to ameloblastic fibroma but show inductive changes formation of hard structures of tooth [13,20]. Overexpression of MDM2 protein in ameloblastomas as compared to adenomatoid odontogenic tumor.
Given the non-neoplastic nature of hamartomas, conservative surgical excision is the treatment of choice. The majority of oral diseases present as growths and masses of varied cellular origin. Table 1 Summary of characteristic features of oral hamartomas. Principles of Development and Diversity.
The identity of the ameloblastic fibroma has always been a source of debate where one school of oral pathologists considers it to be a hamartoma; lral if the ameloblastic fibroma is allowed to progress or left undisturbed it may progress further to ameloblastic fibro-odontoma and then to odontoma while the other group of oral pathologist considers it as neoplastic because of its recurrence of the tumour He inherited the hamartoams mutation from his intellectually and socially normal mother, who was subsequently diagnosed with CS.
Expression of extracellular matrix proteins in ameloblastoma and adenomatoid odontogenic tumors. Immunohistochemical markers like proliferating cell nuclear hamadtomas PCNA and MIB-1 has been studied where it was found that Hamarotmas has been expressed in the mesenchymal component suggesting the higher labeling indices in the Mesenchymal component rather than the epithelial component [18,19].
Smitha K, Smitha GP. Ameloblastic fibroma, ameloblastic fibro-dentinoma and fibro-odontoma Reichart and Philipsen proposed a neoplastic and hamartomatous line of development for the mixed odontogenic tumours. Microscopically, it comprises of odontogenic epithelium and calcifications. Cowden syndrome represents the principal PTEN phosphatase and tensin homolog gene-related disorder which occurs in 1 inpeople.
Suzuki H, Hashimoto K. Focal areas showing calcifications.
Hamartomas of the oral cavity
In a recent article by Ferreira et al  described in detail both the gubernacular cord and the gubernacular canal assessed the possible contribution of these structures in the process of tooth eruption. Glomuvenous malformations Glomuvenous malformation GVM caviity more often in children.
Microscopically, GVM is composed of varying proportion of blood vessels and glomus cells.
Dens evaginatus DE represents an accessory cusp and is predominantly seen in people of Asian descent with a varying incidence of 0. Immunohistochemical detection of p53 and PCNA in ameloblastoma and adenomatoid odontogenic tumor.
Hamartomas of the oral cavity.
Several autosomal dominant inherited tumour syndromes demonstrate prominent features in the oral and maxillofacial region. Report of two cases and review of the literature. Literature relevant to the biological behaviour of AOT Click here to view.
Study on the origin and nature of the adenomatoid odontogenic tumor by immunohistochemistry. Fibrolipomatous hamartoma in a patient with tuberous sclerosis: Odontogenic tumour represents as growth and swellings of variedorigin.
Enzinger and Weiss’s Soft Tissue Tumors. Saudi J Dent Res ;6: We recommend yearly physical examination particularly of skin and thyroid and yearly thyroid ultrasound upon diagnosis.
Hamartomas of the oral cavity Patil S, Rao RS, Majumdar B – J Int Soc Prevent Communit Dent
Proliferating cell nuclear antigen PCNA and p53 protein expression in ameloblastoma and adenomatoid adontogenic tumor. Lippincott Williams and Wilkins; Histopathologically, the proliferating odontogenic epithelium is arranged in form of strands, cords and islands. J Bras Patol Med Lab ; The current terminology used for AOT has had a history of frequent changes with adenoameloblastoma ameloblastic adenomatoid tumour, epithelioma adamantinum, pseudoadenoma adamantinum by Dreybladt, hamartmoas glandular adamantinoma to name a few .